A REVIEW OF TOTOSITE REVIEW

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Employing this approach, Kalbaugh et al. assigned affinity and efficacy roles to positions while in the LBDs of your NR1 and NR2A NMDAR subunits. In situ mutation of residues in immediate connection with bound ligand impacted equally efficacy and affinity, while positions that stabilize the closed cleft conformation and not using a immediate ligand